The role of the latest technology
Sequencing technology is presently going much deeper, and wider. Short-read sequencing is becoming increasingly affordable, ultimately causing much deeper protection of genomes and transcriptomes. We genuinely believe that this can continue steadily to affect research on intercourse chromosome development by broadening the taxonomical range in studies intending at understanding intercourse chromosome transitions and turnovers 83, and allowing studies of sex-biased genes with low phrase. Nonetheless, probably the most revolutionizing advancements that are technological long-read sequencing practices ( ag e.g. solitary molecule real-time sequencing). These procedures will enhance genome assemblies generally speaking, plus in structurally hard areas (e.g. Y and W) in specific 99, to be able to test a few hypotheses in a relative framework, such as the part of transposable elements and structural alterations in intercourse chromosome evolution 8,58.
Also, isoform sequencing of full-length transcripts will be able to shed light that is new sex-specific exon use, and predictions regarding dosage settlement and gene silencing 100. (بیشتر…)